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Julkaisut 2017
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study.
Haghighi M, Johnson SB, Qian X, Lynch KF, Vehik K, Huang S, TEDDY Study Group
Sci Rep.
A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY.
Lönnrot M, Lynch K, Larsson HE, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Ziegler AG, Akolkar B, Krischer J, Hyöty H, TEDDY Study Group
BMC Pediatr
Age at gluten introduction and risk of celiac disease
Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang J, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D, TEDDY STUDY GROUP
Pediatrics
An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children.
Mäkinen M, Simell V, Mykkänen J, Ilonen J, Veijola R, Hyöty H, Knip M, Simell O, Toppari J, Hermann R
J Clin Endocrinol Metab.
Analgesic antipyretic use among young children in the TEDDY study: no association with islet autoimmunity
Lundgren M et al.
BMC Pediatr. 2017 May 16;17(1):127.
Antibodies to lactobacilli and bifidobacteria in young children with different propensity to develop islet autoimmunity
Talja I, Kubo AL, Veijola R, Knip M, Simell O, Ilonen J, Vähä-Mäkilä M, Sepp E, Mikelsaar M, Utt M, Uibo R
J Immunol Res.
Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.
Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM, TEDDY Study Group
JAMA Pediatr
At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study
Johnson SB, Lynch KF, Lee HS, Smith L, Baxter J, Lernmark B, Roth R, Simell T, TEDDY Study Group
J Clin Epidemiol
Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study
Lee HS, Burkhardt BR, McLeod W, Smith S, Eberhard C, Lynch K, Hadley D, Rewers M, Simell O, She JX, Hagopian B, Lernmark A, Akolkar B, Ziegler AG, Krischer JP, TEDDY study group
Diabetes Metab Res Rev
Caesarean Section on The Risk of Celiac Disease in the Offspring: The Teddy Study
Koletzko S. et al.
J Pediatr Gastroenterol Nutr.
Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease
Elding Larsson H, Vehik K, Gesualdo P, Akolkar B, Hagopian W, Krischer J, Lernmark Å, Rewers M, Simell O, She JX, Ziegler A, Haller MJ, TEDDY Study Group
Pediatr Diabetes
Clinical features of celiac disease: a prospective birth cohort.
Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S, TEDDY Study Group
Pediatrics
Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity.
Hagopian W. et al.
Pediatrics.
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study.
Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J, TEDDY Study Group
Sci Rep.
Corrigendum: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study.
Haghighi M, et al
Sci Rep. 2017 May 2;7:39723
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes
Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H
Diabetes
Diagnostic methods for and clinical pictures of polyomavirus primary infections in children, Finland
Chen T, Tanner L, Simell V, Hedman L, Mäkinen M, Sadeghi M, Veijola R, Hyöty H, Ilonen J, Knip M, Toppari J, Simell O, Söderlund-Venermo M, Hedman K
Emerg Infect Dis.
Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study
Beyerlein A, Liu X, Uusitalo UM, Harsunen M, Norris JM, Foterek K, Virtanen SM, Rewers MJ, She JX, Simell O, Lernmark Å, Hagopian W, Akolkar B, Ziegler AG, Krischer JP, Hummel S, TEDDY study group
Am J Clin Nutr
Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes
Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, León-Novelo LG, Vehik K, Casella G, Simell O, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian W, She JX, Krischer JP, Akolkar B, Schatz DA, Atkinson MA, Triplett EW, TEDDY Study Group
Diabetes Care
Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort
Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark Å, Norris JM, Agardh D, TEDDY Study Group
Clin Gastroenterol Hepatol
Factors associated with longitudinal food record compliance in a paediatric cohort study
Yang J, Lynch KF, Uusitalo UM, Foterek K, Hummel S, Silvis K, Aronsson CA, Riikonen A, Rewers M, She JX, Ziegler AG, Simell OG, Toppari J, Hagopian WA, Lernmark Å, Akolkar B, Krischer JP, Norris JM, Virtanen SM, Johnson SB, TEDDY Study Group
Public Health Nutr
Factors associated with maternal-reported actions to prevent type 1 diabetes in the first year of the TEDDY study
Smith LB, Lynch KF, Baxter J, Lernmark B, Roth R, Simell T, Johnson SB, TEDDY Study Group
Diabetes Care
Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life
Kemppainen KM et al.
Clin Gastroenterol Hepatol.
Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life
Kemppainen KM et al.
Clin Gastroenterol Hepatol.
Food consumption and risk of childhood asthma.
Lumia M, Takkinen HM, Luukkainen P, Kaila M, Lehtinen-Jacks S, Nwaru BI, Tuokkola J, Niemelä O, Haapala AM, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM
Pediatr Allergy Immunol
Food diversity in infancy and the risk of childhood asthma and allergies
Nwaru BI, Takkinen HM, Kaila M, Erkkola M, Ahonen S, Pekkanen J, Simell O, Veijola R, Ilonen J, Hyöty H, Knip M, Virtanen SM
J Allergy Clin Immunol.
Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study
Krischer JP. et al.
Diabetes Care. 2017 Sep;40(9):1194-1202.
Genetic susceptibility to type 1 diabetes in childhood – estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity
Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M, Finnish Pediatric Diabetes Register
Pediatr Diabetes
Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies.
Lynch KF. et al.
J Autoimmun.
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study.
Elding Larsson H, Vehik K, Haller MJ, Liu X, Akolkar B, Hagopian W, Krischer J, Lernmark Å, She JX, Simell O, Toppari J, Ziegler AG, Rewers M, TEDDY Study Group
Diabetes
Gut virome sequencing in children with early islet autoimmunity
Kramná L, Kolářová K, Oikarinen S, Pursiheimo JP, Ilonen J, Simell O, Knip M, Veijola R, Hyöty H, Cinek O
Diabetes Care
HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.
Hadley D, Hagopian W, Liu E, She JX, Simell O, Akolkar B, Ziegler AG, Rewers M, Krischer JP, Chen WM, Onengut-Gumuscu S, Bugawan TL, Rich SS, Erlich H, Agardh D, TEDDY Study Group
Am J Gastroenterol
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.
Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG, Lernmark Å, Simell O, Toppari J, Krischer JP, Akolkar B, Rich SS, Agardh D, She JX, TEDDY Study Group
PLoS One
Infant feeding patterns in families with a diabetes history – observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study
Hummel S, Vehik K, Uusitalo U, McLeod W, Aronsson CA, Frank N, Gesualdo P, Yang J, Norris JM, Virtanen SM, TEDDY Study Group
Public Health Nutr
Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes
Kondrashova A, Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hyöty H
Diabetologia
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R
Diabetes
Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study
Köhler M. et al.
Acta Diabetol. 2017 Nov;54(11):1009-1017.
Maternal anxiety about a child’s diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception
Roth R, Lynch K, Lernmark B, Baxter J, Simell T, Smith L, Swartling U, Ziegler AG, Johnson SB, TEDDY Study Group
Pediatr Diabetes
Maternal dietary fatty acid intake during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring
Niinistö S, Takkinen HM, Uusitalo L, Rautanen J, Nevalainen J, Kenward MG, Lumia M, Simell O, Veijola R, Ilonen J, Knip M, Virtanen SM
Br J Nutr.
Maternal dietary folate, folic acid and vitamin D intakes during pregnancy and lactation and the risk of cows’ milk allergy in the offspring
Tuokkola J, Luukkainen P, Kaila M, Takkinen HM, Niinistö S, Veijola R, Virta LJ, Knip M, Simell O, Ilonen J, Virtanen SM
Br J Nutr.
Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study
Yang J et al.
Br J Nutr. 2017 Feb;117(3):466-472.
No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children
Reinert-Hartwall L, Honkanen J, Härkönen T, Ilonen J, Simell O, Peet A, Tillmann V, Lamberg-Allardt C, Virtanen SM, Knip M, Vaarala O, DIABIMMUNE Study Group
Diabetes Metab Res Rev
Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children.
Elding Larsson H. et al.
Diabetologia.
Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing.
Lernmark B, Lynch K, Baxter J, Roth R, Simell T, Smith L, Swartling U, Johnson SB, Teddy Study Group
J Diabetes Res.
Predicting Later Study Withdrawal in Participants Active in a Longitudinal Birth Cohort Study for 1 Year: The TEDDY Study
Johnson SB, Lynch KF, Baxter J, Lernmark B, Roth R, Simell T, Smith L, TEDDY Study Group
J Pediatr Psychol
Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).
Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ, TEDDY Study Group
Diabetes Care
Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes
Yang J, Lernmark A, Uusitalo UM, Lynch KF, Veijola R, Winkler C, Larsson HE, Rewers M, She JX, Ziegler AG, Simell OG, Hagopian WA, Akolkar B, Krischer JP, Vehik K, the TEDDY Study Group
Int J Obes (Lond)
The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History to the Progression from Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report.
Krischer JP. et al.
Diabetes.
Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.
Vehik K, Lynch KF, Schatz DA, Akolbar B, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Lernmark Å, Bonifacio E, Krischer JP, TEDDY Study Group
Diabetes Care
Risk of pediatric celiac disease according to HLA haplotype and country
Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D, TEDDY Study Group
N Engl J Med
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study
Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J, TEDDY Study Group
Diabetes
The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.
Krischer JP, Lynch KF, Schatz DA, Ilonen J, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Bonifacio E, TEDDY Study Group
Diabetologia
The HLA-B*39 allele increases type 1 diabetes risk conferred by HLA-DRB1*04:04-DQB1*03:02 and HLA-DRB1*08-DQB1*04 class II haplotypes
Mikk ML, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Simell O, Knip M, Ilonen J, Finnish Paediatric Diabetes Register
Hum Immunol.
The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History to the Progression from Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report.
Krischer JP. et al.
Diabetes.