DIPP-julkaisut

DIPP publications

Peer-reviewed original scientific articles

1996

1. Ilonen J, Reijonen H, Knip M, Simell O. Population-based genetic screening for IDDM susceptibility as a source of HLA-genotyped control subjects (Letter). Diabetologia 1996;39:123. doi: 10.1007/BF00400423.

1997

2. Halminen M, Ilonen J, Julkunen I, Ruuskanen O, Simell O, Mäkelä MJ. Expression of MxA Protein in Blood Lymphocytes Discriminates between Viral and Bacterial Infections in Febrile Children. Pediatr Res 1997;41:647-650. doi: 10.1203/00006450-199705000-00008.

1998

3. Andersson A-M, Toppari J, Haavisto A-M, Petersen JH, Simell T, Simell O, Skakkebæk NE. Longitudinal Reproductive Hormone Profiles in Infants: Peak of Inhibin B Levels in Infant Boys Exceeds Levels in Adult Men. J Clin Endocrinol Metab. 1998;83:675-681. doi: 10.1210/jcem.83.2.4603.

4. Hahl J, Simell T, Ilonen J, Knip M, Simell O. Costs of predicting IDDM. Diabetologia 1998;41:7985. doi: 10.1007/s001250050870.

5. Ilonen J, Simell O, Knip M, Åkerblom HK. Screening for genetic IDDM risk and prevention trials in infancy. Diabetes Metab Rev 1998;14:188. doi: 10.1002/(SICI)10990895(199806)14:2<188::AID-DMR1210>3.0.CO;2-0.

6. Juhela S, Hyöty H, Lönnrot M, Roivainen M, Simell O, Ilonen J. Enterovirus Infections and Enterovirus Specific T-Cell Responses in Infancy. J Med Virol 1998;54:226-232. doi: 10.1002/(SICI)1096-9071.

7. Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz EI, Kovalchuk L, Sochnev A, Adojaan B, Podar T, Knip M, Simell O, Koskenvuo M, Åkerblom HK, Ilonen J. Distribution of insulindependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of eastern Baltic region. Tissue Antigens 1998;52:473477. doi: 10.1111/j.1399-0039.1998.tb03074.x.

1999

8. Juhela S, Hyöty H, Uibo R, Meriste SH, Uibo O, Lönnrot M, Halminen M, Simell O, Ilonen J. Comparison of enterovirus-specific cellular immunity in two populations of young children vaccinated with inactivated or live poliovirus vaccines. Clin Exp Immunol 1999;117:100-105. doi: 10.1046/j.1365-2249.1999.00954.x.

9. Nejentsev S, Sjöroos M, Soukka T, Knip M, Simell O, Lövgren T, Ilonen J. Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci. Diabetic Med 1999;16:985-992. doi: 10.1046/j.1464-5491.1999.00186.x.

10. Vaarala O, Knip M, Paronen J, Hämäläinen A-M, Muona P, Väätäinen M, Ilonen J, Simell O, Åkerblom HK. Cow´s Milk Formula Feeding Induces Primary Immunization to Insulin in Infants at Genetic Risk for Type 1 Diabetes. Diabetes 1999;48:1389-1394. doi: 10.2337/diabetes.48.7.1389.

2000

11. Ilonen J, Reijonen H, Green A, Reunanen A, Knip M, Simell O, Åkerblom HK, the Childhood Diabetes in Finland Study Group. Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with Type 1 diabetes susceptibility. Eur J Immunogenet 2000;27:225-230. doi: 10.1046/j.1365-2370.2000.00223.x.

12. Juhela S, Hyöty H, Roivainen M, Härkönen T, Putto-Laurila A, Simell O, Ilonen J. T-Cell Responses to Enterovirus Antigens in Children with Type 1 Diabetes. Diabetes 2000;49:13081313. doi:10.2337/diabetes.49.8.1308.

13. Lönnrot M, Korpela K, Knip M, Ilonen J, Simell O, Korhonen S, Savola K, Muona P, Simell T, Koskela P, Hyöty H. Enterovirus Infection as a Risk Factor for β-Cell Autoimmunity in a Prospectively Observed Birth Cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes 2000;49:1314-1318. doi:10.2337/diabetes.49.8.1314.

14. Nejentsev S, Laine A-P. Simell O, Ilonen J. Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns. Tissue Antigens 2000;55:568570. doi: 10.1034/j.1399-0039.2000.550608.x

15. Nejentsev S, Gombos Z, Laine A-P, Veijola R, Knip M, Simell O, Vaarala O, Åkerblom HK, Ilonen J. Non-Class II HLA Gene Associated with Type 1 Diabetes Maps to the 240-kb Region Near HLA-B. Diabetes 2000;49:2217-2221. doi:10.2337/diabetes.49.12.2217.

2001

16. Halminen M, Simell O, Knip M, Ilonen J. Cytokine Expression in Unstimulated Peripheral Blood Mononuclear Cells of Children with Type 1 Diabetes and Subjects Positive for DiabetesAssociated Autoantibodies. Scand J Immunol 2001;53:510-513. doi: 10.1046/j.13653083.2001.00904.x.

17. Halminen M, Juhela S, Vaarala O, Simell O, Ilonen J. Induction of Interferon-γ and IL-4 Production by Mitogen and Specific Antigens in Peripheral Blood Lymphocytes of Type 1 Diabetes Patients. Autoimmunity 2001;34:1-8. doi: 10.3109/08916930108994120.

18. Heino L, Lönnrot M, Knip M, Kupila A, Erkkilä S, Toivonen A, Vähäsalo P, Ilonen J, Simell O, Hyöty H. No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children. Clin Exp Immunol 2001;126:432-436. doi: 10.1111/j.13652249.2001.01691.x.

19. Kimpimäki T, Erkkola M, Korhonen S, Kupila A, Virtanen SM, Ilonen J, Simell O, Knip M. Shortterm exclusive breastfeeding predisposes young children with increased genetic risk of type 1 diabetes to progressive beta-cell autoimmunity. Diabetologia 2001;44:63-69. doi: 10.1007/s001250051581.

20. Kimpimäki T, Kupila A, Hämäläinen A-M, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M. The First Signs of β-Cell Autoimmunity Appear in Infancy in Genetically Suspectible Children from the General Population: The Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metabol 2001;86:4782-4788. doi: http://dx.doi.org/10.1210/jcem.86.10.7907.

21. Kupila A, Muona P, Simell T, Arvilommi P, Savolainen H, Hämäläinen A-M, Korhonen S, Kimpimäki T, Sjöroos M, Ilonen J, Knip M, Simell O. Feasibility of genetic and immunological prediction of Type 1 diabetes in a population-based birth cohort. Diabetologia 2001;44:290297. doi: 10.1007/s001250051616.

22. Marttila J, Juhela S, Vaarala O, Hyöty H, Roivainen M, Hinkkanen A, Vilja P, Simell O, Ilonen J. Responses of Coxsackievirus B4-Specific T-Cell Lines to 2C Protein – Characterization of Epitopes with Special Reference to the GAD65 Homology Region. Virology 2001;284:131141. doi: 10.1006/viro.2001.0917.

23. Sadeharju K, Lönnrot M, Kimpimäki T, Savola K, Erkkilä S, Kalliokoski T, Savolainen P, Koskela P, Ilonen J, Simell O, Knip M, Hyöty H. Enterovirus antibody levels during the first two years
of life in prediabetic autoantibody-positive children. Diabetologia 2001;44:818-823. doi: 10.1007/s001250100560.

2002

24. Blomqvist M, Juhela S, Erkkilä S, Korhonen S, Simell T, Kupila A, Vaarala O, Simell O, Knip M, Ilonen J. Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life. Clin Exp Immunol 2002;128:511-515. doi: 10.1046/j.13652249.2002.01842.x.

25. Hämäläinen A-M, Ilonen J, Simell O, Savola K, Kulmala P, Kupila A, Simell T, Erkkola R, Knip M. Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers. Diabetes Metab Res Rev 2002;18:57-63. doi: 10.1002/dmrr.232.

26. Keskinen P, Korhonen S, Kupila A, Veijola R, Erkkilä S, Savolainen H, Arvilommi P, Simell T, Ilonen J, Knip M, Simell O. First-phase insulin response in young healthy children at genetic and immunological risk for Type 1 diabetes. Diabetologia 2002;45:1639-1648. doi: 10.1007/s00125-002-0981-8.

27. Kimpimäki T, Kulmala P, Savola K, Kupila A, Korhonen S, Simell T, Ilonen J, Simell O, Knip M. Natural History of β-Cell Autoimmunity in Young Children with Increased Genetic Susceptibility to Type 1 Diabetes Recruited from the General Population. J Clin Endocrinol Metab 2002;87:4572-4579. doi: 10.1210/jc.2002-020018.

28. Kupila A, Keskinen P, Simell T, Erkkilä S, Arvilommi P, Korhonen S, Kimpimäki T, Sjöroos M, Ronkainen M, Ilonen J, Knip M, Simell O. Genetic Risk Determines the Emergence of Diabetes-Associated Autoantibodies in Young Children. Diabetes 2002;51:646-651. doi:10.2337/diabetes.51.3.646

29. Turpeinen H, Laine A-P, Nejentsev S, Sjöroos M, Simell O, Veijola R, Knip M, Åkerblom HK, Ilonen J. CD86 gene polymorphisms: no association with Type 1 diabetes among Finnish subjects. Diabetologia 2002;45:1041-1042. doi: 10.1007/s00125-002-0870-1.

30. Vaarala O, Klemetti P, Juhela S, Simell O, Hyöty H, Ilonen J. Effect of coincident enterovirus infection and cow´s milk exposure on immunisation to insulin in early infancy. Diabetologia 2002;45:531-534. doi: 10.1007/s00125-002-0787-8.

2003

31. Gombos Z, Hermann R, Veijola R, Knip M, Simell O, Pollanen P, Ilonen J. Androgen receptor gene exon 1 CAG polymorphism in Finnish patients with childhood-onset type 1 diabetes. Eur J Endocrinol 2003;149:597-600. doi: 10.1530/eje.0.1490597

32. Hahl J, Simell T, Kupila A, Keskinen P, Knip M, Ilonen J, Simell O. A Simulation Model for Estimating Direct Costs of Type 1 Diabetes Prevention. PharmacoEconomics 2003;21:295303. doi: 10.2165/00019053-200321050-00001.

33. Kukko M, Kimpimäki T, Kupila A, Korhonen S, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M. Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study. Diabetologia 2003;46:65-70. doi: 10.1007/s00125-002-0976-5.

34. Kupila A, Sipilä J, Keskinen P, Simell T, Knip M, Pulkki K, Simell O. Intranasally administered insulin intended for prevention of type 1 diabetes – a safety study in healthy adults. Diabetes Metab Res Rev 2003;19:415-420. doi: 10.1002/dmrr.397.

35. Salminen K, Sadeharju K, Lönnrot M, Vähäsalo P, Kupila A, Korhonen S, Ilonen J, Simell O, Knip M, Hyöty H. Enterovirus Infections Are Associated With the Induction of β-Cell Autoimmunity in a Prospective Birth Cohort Study. J Med Virol 2003;69:91-98. doi: 10.1002/jmv.10260.

36. Turpeinen H, Hermann R, Vaara S, Laine A-P, Simell O, Knip M, Veijola R, Ilonen J. Vitamin D receptor polymorphisms: no association with type 1 diabetes in the Finnish population. Eur J Endocrinol 2003;149:591-596. doi. 10.1530/eje.0.1490591.

2004

37. Hermann R, Bartsocas CS, Soltész Gy, Vazeou A, Paschou P, Bozas E, Malamitsi-Puchner A, Simell O, Knip M, Ilonen J. Genetic screening for individuals at high risk for type I diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence. Diabetes Metab Res Rev 2004;20:322-329. doi: 10.1002/dmrr.455.

38. Hoppu S, Ronkainen MS, Kimpimäki T, Simell S, Korhonen S, Ilonen J, Simell O, Knip M. Insulin Autoantibody Isotypes during the Prediabetic Process in Young Children with Increased Genetic Risk of Type 1 Diabetes. Pediatric Res 2004;55:236-242. 10.1203/01.PDR.0000100905.41131.3F.

39. Kukko M, Virtanen SM, Toivonen A, Simell S, Korhonen S, Ilonen J, Simell O, Knip M. Geographical Variation in Risk HLA-DQB1 Genotypes for Type 1 Diabetes and Signs of βCell Autoimmunity in a High-Incidence Country. Diabetes Care 2004;27:676-681. doi: 10.2337/diacare.27.3.676.

40. Laine AP, Hermann R, Knip M, Simell O, Åkerblom HK, Ilonen J. The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population. Tissue Antigens 2004;63:72-74. doi: 10.1111/j.13990039.2004.00153.x.

41. Marjamäki L, Räsänen M, Uusitalo L, Ahonen S, Veijola R, Knip M, Virtanen SM. Use of Vitamin D and other Dietary Supplements by Finnish Children at the age 2 and 3 years. Int J Vitam Nutr Res 2004;74:27-34. doi: 10.1024/0300-9831.74.1.27

42. Mäkelä M, Marttila J, Simell O, Ilonen J. Rotavirus-specific T-cell responses in young prospectively followed-up children. Clin Exp Immunol 2004;137:173-178. doi: 10.1111/j.13652249.2004.02509.x.

43. Salminen K, Vuorinen T, Oikarinen S, Helminen M, Simell S, Knip M, Ilonen J, Simell O, Hyöty H. Isolation of enterovirus strains from children with preclinical Type 1 diabetes. Diab Med 2004;21:156-164. doi: 10.1111/j.1464-5491.2004.01097.x.

2005

44. Erkkola M, Kronberg-Kippilä C, Savilahti E, Kenward M, Salonen M, Ilonen J, Knip M, Åkerblom HK, Virtanen SM. Maternal consumption of dairy products during pregnancy and lactation, and the development of cow’s milk antibodies in the offspring. Acta Pædiatr 2005;94:696-704. doi: 10.1080/08035250510029523.

45. Erkkola M, Pigg H-M, Virta-Autio P, Hekkala A, Hyppönen E, Knip M, Virtanen SM. Infant feeding patterns in the Finnish type 1 diabetes prediction and prevention nutrition study cohort. Eur J Clin Nutr 2005;58:107-113. doi: 10.1038/sj.ejcn.1602045.

46. Hermann R, Mantere J, Lipponen K, Veijola R, Soltesz G, Otonkoski T, Simell O, Knip M, Ilonen J. Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations. Diabetes 2005;54:2816-2819. doi: 10.2337/diabetes.54.9.2816.

47. Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lähde J, Simell O, Knip M, Ilonen J. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral betacell autoimmunity. Diabetologia 2005;48:1766-1775. doi: 10.1007/s00125-005-1844-x.

48. Kukko M, Kimpimäki T, Korhonen S, Kupila A, Simell S, Veijola R, Simell T, Ilonen J, Simell O, Knip M. Dynamics of Diabetes-Associated Autoantibodies in Young Children with Human Leukocyte Antigen-Conferred Risk of Type 1 Diabetes Recruited from the General Population. J Clin Endocrinol Metab 2005;90:2712-7. doi: 10.1210/jc.2004-1371.

49. Öling V, Marttila J, Ilonen J, Kwok WW, Nepom G, Knip M, Simell O, Reijonen H. GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risksubjects. J Autoimmun 2005;25:235-43. doi: 10.1016/j.jaut.2005.09.018.

50. Simell S, Kupila A, Hoppu S, Hekkala A, Simell T, Ståhlberg M-R, Viander M, Hurme T, Knip M, Ilonen J, Hyöty H, Simell O. Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand J Gastroenterol 2005;40:1182-1191. doi: 10.1080/00365520510024034.

51. Waris ME, Koskinen JO, Simell O, Knip M, Ilonen J. Onset of β-cell autoimmunity is not associated with elevated concentration of C-reactive protein in children at genetic risk for Type 1 diabetes. Diabetic Med 2005;22:1123-1124. doi: 10.1111/j.1464-5491.2005.01593.x.

52. Westerlund A, Ankelo M, Ilonen J, Knip M, Simell O, Hinkkanen AE. Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic acid decarboxylase (GAD65) during progression to type 1 diabetes. J Autoimmun 2005;24:153-167. doi: 10.1016/j.jaut.2004.12.001.

2006

53. Arkkola T, Uusitalo U, Pietikäinen M, Metsälä J, Kronberg-Kippilä C, Erkkola M, Veijola R, Knip M, Virtanen SM, Ovaskainen M-L. Dietary intake and use of dietary supplements in relation to demographic variables among pregnant Finnish women. Br J Nutr 2006;96:913-920. doi: 10.1017/BJN20061929.

54. Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J. Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg628Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia 2006;49:1198-1208. doi: 10.1007/s00125-0060225-4.

55. Hoppu S, Härkönen T, Ronkainen MS, Simell S, Hekkala A, Toivonen A, Ilonen J, Simell O. Knip M. IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes. Clin Exp Immunol 2006;144:59-66. doi: 10.1111/j.1365-2249.2006.03033.x.

56. Kukko M, Toivonen A, Kupila A, Korhonen S, Keskinen P, Veijola R, Virtanen SM, Ilonen J, Simell O, Knip M, Familial clustering of β-cell autoimmunity in initially non-diabetic children. Diabetes Metab Res Rev 2006;22:53-58. doi: 10.1002/dmrr.584.

57. Mäkelä M, Öling V, Marttila J, Waris M, Knip M, Simell, Ilonen J. Rotavirus-specific Tcell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes. Clin Exp Immunol 2006;145:261-270. doi: 10.1111/j.13652249.2006.03146.x.

58. Mäkelä M, Vaarala O, Hermann R, Salminen K, Vahlberg T, Veijola R, Hyöty H, Knip M, Simell O, Ilonen J. Enteral virus infections in early childhood and an enhanced type 1 diabetesassociated antibody response to dietary insulin. J Autoimmun 2006;27:54-61. doi: 10.1016/j.jaut.2006.04.003.

59. Ronkainen MS, Hoppu S, Korhonen S, Simell S, Veijola R, Ilonen J, Simell O, Knip M. Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes. Eur J Endocrinol 2006;155:633-642. doi: 10.1530/eje.1.02271.

60. Räsänen M, Kronberg-Kippilä C, Ahonen S, Uusitalo L, Kautiainen S, Erkkola M, Veijola R, Knip M, Kaila M, Virtanen SM. Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors. Eur J Clin Nutr 2006;60:1317-1322. doi: 10.1038/sj.ejcn.1602459.

61. Simonen P, Korhonen T, Simell T, Keskinen P, Kärkkäinen M, Knip M, Ilonen J, Simell O. Parental Reactions to Information About Increased Genetic Risk of Type 1 Diabetes Mellitus in Infants. Arch Pediatr Adolesc Med 2006;160:1131-1136. doi: 10.1001/archpedi.160.11.1131.

62. Toivonen AM, Kimpimäki T, Kupila A, Korhonen S, Hyöty H, Virtanen SM, Ilonen J, Simell O, Knip M. Soluble adhesion molecules in young children with signs of β-cell autoimmunity – prospective follow-up from birth. Diabetes Metab Res Rev 2006;22:176-183. doi: 10.1002/dmrr.597.

63. Williams CH, Oikarinen S, Tauriainen S, Salminen K, Hyöty H, Stanway G. Molecular Analysis of an Echovirus 3 Strain Isolated From an Individual Concurrent with the Appearance of Islet Cell and IA-2 Autoantibodies. J Clin Microbiol 2006;44:441-448. doi: 10.1128/JCM.44.2.441– 448.2006.

64. Virtanen SM, Kenward, MG, Erkkola M, Kautiainen S, Kronberg-Kippilä C, Hakulinen T, Ahonen S, Uusitalo L, Niinistö S, Veijola R, Simell O, Ilonen J, Knip M. Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 2006;49:1512-1521. doi: 10.1007/s00125-0060236-1.

65. Vuorinen P, Rulli M, Kuusisto A, Simell S, Simell T, Vahlberg T, Ilonen J, Hyöty H, Knip M, Simell O. Time-Resolved Fluorescence Imaging of Islet Cell Autoantibodies. Ann NY Acad Sci 2006;1079:226-228. doi: 10.1196/annals.1375.035.

2007

66. Ankelo M, Kleimola V, Simell S, Simell O, Knip M, Jokisalo E, Tarkia M, Westerlund A, He Q, Viander M, Ilonen J, Hinkkanen AE. Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing coeliac disease. Clin Exp Immunol 2007;150:285-293. doi: 10.1111/j.1365-2249.2007.03487.x

67. Ankelo M, Westerlund A, Blomberg K, Knip M, Ilonen J, Hinkkanen AE. Time-Resolved Immunofluorometric Dual-Label Assay for Simultaneous Detection of Autoantibodies to GAD65 and IA-2 in Children with Type 1 Diabetes. Clin Chem 2007;53:472-479. doi: 10.1373/clinchem.2005.064568.

68. Öling V, Marttila J, Knip M, Simell O, Ilonen J. Circulating CD4+CD25high Regulatory T Cells and Natural Killer T Cells in Children with Newly Diagnosed Type 1 Diabetes or with DiabetesAssociated Autoantibodies. Ann NY Acad Sci 2007;1107:363-372. doi: 10.1196/annals.1381.038.

69. Simell S, Hoppu S, Hekkala A, Simell T, Ståhlberg M-R, Viander M, Yrjänäinen H, Grönlund J, Markula P, Simell V, Knip M, Ilonen J, Hyöty H, Simell O. Fate of Five Celiac DiseaseAssociated Antibodies During Normal Diet in Genetically At-Risk Children Observed from Birth in a Natural History Study. Am J Gastroenterol 2007;102:2026-2035. doi: 10.1111/j.1572-0241.2007.01360.x.

70. Tauriainen S, Martiskainen M, Oikarinen S, Lönnrot M, Viskari H, Ilonen J, Simell O, Knip M, Hyöty H. Human Parechovirus 1 Infections in Young Children – No Association With Type 1 Diabetes. J Med Virol 2007;79:457-462. doi: 10.1002/jmv.20831.

71. Westerlund A, Ankelo M, Simell S, Ilonen J, Knip M, Simell O, Hinkkanen AE. Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibody during development of coeliac disease. Clin Exp Immunol 2007;148:230-240. doi: 10.1111/j.1365-2249.2007.03336.x.

2008

72. Aarnisalo J, Veijola R, Vainionpää R, Simell O, Knip M, Ilonen J. Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes. Diabetologia 2008;51:769-772. doi: 10.1007/s00125-008-0945-8.

73. Aarnisalo J, Treszl A, Svec P, Marttila J, Öling V, Simell O, Knip M, Körner A, Madacsy L, Vasarhelyi B, Ilonen J, Hermann R. Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J Autoimmun 2008;31:13-21. doi: 10.1016/j.jaut.2008.01.001.

74. Aittoniemi J, Turpeinen H, Tiittanen M, Knip M, Simell O, Ilonen J, Vaarala O. Relation among mannose-binding lectin 2 genotype, β-cell autoantibodies, and risk for type 1 diabetes in Finnish children. Hum Immunol 2008;69:108-111. doi: 10.1016/j.humimm.2008.01.007.

75. Arkkola T, Uusitalo U, Kronberg-Kippilä C, Männistö S, Virtanen M, Kenward MG, Veijola R, Knip M, Ovaskainen M-L, Virtanen SM. Seven distinct dietary patterns identified among pregnant Finnish women – associations with nutrient intake and sociodemographic factors. Public Health Nutr 2008;11:176-182. doi: 10.1017/S1368980007000420.

76. Marttila J, Huttunen S, Vaarala O, Suzuki K, Elliott JF, Närvänen A, Knip M, Simell O, Ilonen J. T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple β-cell autoantibodies. J Autoimmun 2008;31:142-148. doi: 10.1016/j.jaut.2008.04.024.

77. Näntö-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipilä JI, Haavisto L, Siltala M, Tuominen J, Hakalax J, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 2008;372:1746-1755. doi: 10.1016/S0140-6736(08)61309-4.

78. Oikarinen M, Tauriainen S, Honkanen T, Vuori K, Karhunen P, Vasama-Nolvi C, Oikarinen S, Verbeke C, Blair GE, Rantala I, Ilonen J, Simell O, Knip M, Hyöty H. Analysis of pancreas tissue in a child positive for islet cell antibodies. Diabetologia 2008;51:1796-1802. doi: 10.1007/s00125-008-1107-8.

79. Orešič M, Simell S, Sysi-Aho, M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med, 2008;205:2975-2984. doi: 10.1084/jem.20081800.

80. Tauriainen S, Oikarinen S, Taimen K, Laranne J, Sipilä M, Lönnrot M, Ilonen J, Simell O, Knip M, Hyöty H. Temporal Relationship between Human Parechovirus 1 Infection and Otitis Media in Young Children. J Infect Dis 2008;198:35-40. doi: 10.1086/588677.

81. Tuokkola J, Kaila M, Pietinen P, Simell O, Knip M, Virtanen SM. Agreement between parental reports and patient records in food allergies among infants and young children in Finland. J Eval Clin Pract 2008;14:984-989. doi: 10.1111/j.1365-2753.2007.00922.x.

82. Uusitalo L, Nevalainen J, Niinistö S, Alfthan G, Sundvall J, Korhonen T, Kenward MG, Oja H, Veijola R, Simell O, Ilonen J, Knip M, Virtanen SM. Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus. Diabetologia 2008;51:773-780. doi: 10.1007/s00125-008-0959-2.

83. Uusitalo L, Kenward MG, Virtanen SM, Uusitalo U, Nevalainen J, Niinistö S, Kronberg-Kippilä C, Ovaskainen M-L, Marjamäki L, Simell O, Ilonen J, Veijola R, Knip M. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child. Am J Clin Nutr 2008;88:458-464. doi: NA.

84. Uusitalo L, Uusitalo U, Ovaskainen M-L, Niinistö S, Kronberg-Kippilä C, Marjamäki L, Ahonen S, Kenward MG, Knip M, Veijola R, Virtanen SM. Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy. Public Health Nutr 2008;11:1379-1388. doi: 10.1017/S1368980008003522.

2009

85. Douroudis K, Laine A-P, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K. Association of CTLA4 but not ICOS polymorphisms with Type 1 Diabetes in two populations with different disease rates. Hum Immunol 2009;70:536-539. doi: 10.1016/j.humimm.2009.04.023.

86. Erkkola M, Kaila M, Nwaru BI, Kronberg-Kippilä C, Ahonen S, Nevalainen J, Veijola R, Pekkanen J, Ilonen J, Simell O, Knip M, Virtanen SM. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 2009;39:875-882. doi: 10.1111/j.1365-2222.2009.03234.x.

87. Erkkola M, Kronberg-Kippilä C, Kyttälä P, Lehtisalo J, Reinivuo H, Tapanainen H, Veijola R, Knip M, Ovaskainen M-L, Virtanen SM. Sucrose in the diet of 3-year-old Finnish children: sources, determinants and impact on food and nutrient intake. Br J Nutr 2009;101:1209-1217. doi: 10.1017/S0007114508057619.

88. Goldstein E, Hermann R, Renfors TJ, Näntö-Salonen KM, Korhonen T, Kärkkäinen M, Veijola RK, Knip M, Simell TT, Simell OG. From Genetic Risk Awareness to Overt Type 1 Diabetes: Parental stress in a placebo-controlled prevention trial. Diabetes Care 2009;32:2181-2183. doi: 10.2337/dc09-0423.

89. Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J. Interplay between PTPN22 C1858T polymorphism and cow´s milk formula exposure in type 1 diabetes. J Autoimmun 2009;33:155-164. doi: 10.1016/j.jaut.2009.04.003.

90. Oikarinen S, Tauriainen S, Viskari H, Simell O, Knip M, Virtanen S, Hyöty H. PCR inhibition in stool samples in relation to age of infants. J Clin Virol 2009;44:211-214. doi: 10.1016/j.jcv.2008.12.017.

91. Ovaskainen M-L, Nevalainen J, Uusitalo L, Tuokkola JJ, Arkkola T, Kronberg-Kippilä C, Veijola R, Knip M, Virtanen SM. Some similarities in dietary clusters of pre-school children and their mothers. Br J Nutr 2009;102:443-452. doi: 10.1017/S0007114508191218.

92. Siljander H, Härkönen T, Hermann R, Simell S, Hekkala A, Salonsaari R-T, Simell T, Simell O, Ilonen J, Veijola R, Knip M. Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility. Diabetes Metab Res Rev 2009;25:615-622. doi: 10.1002/dmrr.998.

93. Siljander HTA, Simell S, Hekkala A, Lähde J, Simell T, Vähäsalo P, Veijola R, Ilonen J, Simell O, Knip M. Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population. Diabetes 2009;58:2835-2842. doi: 10.2337/db08-1305.

94. Uusitalo U, Arkkola T, Ovaskainen M-L, Kronberg-Kippilä C, Kenward MG, Veijola R, Simell O, Knip M, Virtanen SM. Unhealthy dietary patterns are associated with weight gain during pregnancy among Finnish women. Public Health Nutr 2009;12:2392-2399. doi: 10.1017/S136898000900528X.

2010

95. Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimm 2010;35:70-76. doi: 10.1016/j.jaut.2010.03.001.

96. Erkkola M, Salmenhaara M, Kronberg-Kippilä C, Ahonen S, Arkkola T, Uusitalo L, Pietinen P, Veijola R, Knip M, Virtanen SM. Determinants of breast-feeding in a Finnish birth cohort. Public Health Nutr 2010;13:504-513. doi: 10.1017/S1368980009991777.

97. Erkkola M, Kyttälä P, Kronberg-Kippilä C, Ovaskainen M-L, Tapanainen H, Veijola R, Simell O, Knip M, Virtanen SM. Alle kouluikäisten lasten ruoankäyttö ja ravinnonsaanti. (In Finnish with English summary: The healthier future resides in family meals; The Diet of Finnish Preschoolers). Suomen lääkärilehti (Finnish Medical Journal) 2010;65:2665-2673. doi: NA.

98. Hekkala A, Reunanen A, Koski M, Knip M, Veijola R; Finnish Pediatric Diabetes Register. AgeRelated Differences in the Frequency of Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents. Diabetes Care 2010;33:1500-2. doi: 10.2337/dc09-2344.

99. Jermendy A, Szatmári I, Laine AP, Lukács K, Horváth KH, Körner A, Madácsy L, Veijola R, Simell O, Knip M, Ilonen J, Hermann R, The Finnish Paediatric Diabetes Registry, The HUNT1DGENES program. The interferon-induced helicase (IFIH1) Ala946Thr polymorphism is associated with type 1 diabetes both in the high incidence Finnish and the medium incidence Hungarian population. Diabetologia 2010;53:98-102. doi: 10.1007/s00125-009-1561-y.

100. Kyttälä P, Erkkola M, Kronberg-Kippilä C, Tapanainen H, Veijola R, Simell O, Knip M, Virtanen SM. Food consumption and nutrient intake in Finnish 1-6-year-old children. Pub Health Nutr 2010;13:947-956. doi: 10.1017/S136898001000114X.

101. Lehtisalo J, Erkkola M, Tapanainen H, Kronberg-Kippilä C, Veijola R, Knip M, Virtanen SM. Food consumption and nutrient intake in day care and at home in 3-year-old Finnish children. Publ Health Nutr 2010;13:957-964. doi: 10.1017/S1368980010001151.

102. Lipponen K, Gombos Z, Kiviniemi M, Siljander H, Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J. Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes. Diabetes 2010;59:3253-3256. doi: 10.2337/db10-0167.

103. Marjamäki L, Niinistö S, Kenward MG, Uusitalo L, Uusitalo U, Ovaskainen M-L, KronbergKippilä C, Simell O, Veijola R, Ilonen J, Knip M, Virtanen SM. Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring. Diabetologia 2010;53:1599-1607. doi: 10.1007/s00125-010-1734-8.

104. Nwaru BI, Ahonen S, Kaila M, Erkkola M, Haapala A-M, Kronberg-Kippilä C, Veijola R, Ilonen J, Simell O, Knip M, Virtanen SM. Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 2010;21:2937. doi: 10.1111/j.1399-3038.2009.00949.x.

105. Nwaru BI, Erkkola M, Ahonen S, Kaila M, Haapala A-M, Kronberg-Kippilä C, Salmelin R, Veijola R, Ilonen J, Simell O, Knip M, Virtanen SM. Age at the Introduction of Solid Foods During the First Year and Allergic Sensitization at Age 5 Y. Pediatrics 2010;125:50-59. doi: 10.1542/peds.2009-0813.

106. Prasad M, Lumia M, Erkkola M, Tapanainen H, Kronberg-Kippilä C, Tuokkola J, Uusitalo U, Simell O, Veijola R, Knip M, Ovaskainen M-L,Virtanen SM. Diet composition of pregnant Finnish women: changes over time and across seasons. Publ Health Nutr 2010;13:939-946. doi: 10.1017/S1368980010001138.

107. Salmenhaara M, Uusitalo L, Uusitalo U, Kronberg-Kippilä C, Sinkko H, Ahonen S, Veijola R, Knip M, Kaila M, Virtanen SM. Diet and weight gain characteristics of pregnant women with gestational diabetes. Eur J Clin Nutr 2010;64:1433-1440. doi: 10.1038/ejcn.2010.167.

108. Simell S, Hoppu S, Simell T, Ståhlberg M-R, Viander M, Routi T, Simell V, Veijola R, Ilonen J, Hyöty H, Knip M, Simell O. Age at Development of Type 1 Diabetes and Celiac DiseaseAssociated Antibodies and Clinical Disease in Genetically Susceptible Children Observed From Birth. Diabetes Care 2010;33:774-779. doi: 10.2337/dc09-1217.

109. Tuokkola J, Kaila M, Kronberg-Kippilä C, Sinkko HK Klaukka T, Pietinen P, Veijola R, Simell O, Ilonen J, Knip M, Virtanen SM. Cow´s milk allergy in children: adherence to a therapeutic elimination diet and reintroduction of milk into the diet. Eur J Clin Nutr 2010;64:1080-1085. doi: 10.1038/ejcn.2010.132.

110. Tuokkola J, Luukkainen P, Kaila M, Tapanainen H, Klaukka T, Veijola R, Simell O, Knip M, Virtanen SM. Validation of a questionnaire on cow’s milk allergy: parental reports and physicians’ diagnosis. Acta Paediatr 2010;99:1273-1275. doi: 10.1111/j.16512227.2010.01772.x.

111. Virtanen SM, Kaila M, Pekkanen J, Kenward MG, Uusitalo U, Pietinen P, Kronberg-Kippilä C, Hakulinen T, Simell O, Ilonen J, Veijola R, Knip M. Early introduction of oats associated with decreased risk of persistent asthma and early introduction of fish with decreased risk of allergic rhinitis. Brit J Nutr 2010;103:266-273. doi: 10.1017/S0007114509991541.

112. Virtanen SM, Niinistö S. Nevalainen J, Salminen I, Takkinen H-M, Kääriä S, Uusitalo L, Alfthan G, Kenward MG, Veijola R, Simell O, Ilonen J, Knip M. Serum fatty acids and risk of advanced β-cell autoimmunity: a nested case-control study among children with HLA-conferred susceptibility to type 1 diabetes. Eur J Clin Nutr 2010;64:792-799. doi: 10.1038/ejcn.2010.75

2011

113. Arkkola T, Kautiainen S, Takkinen H-M, Kenward, MG, Nevalainen J, Uusitalo U, Simell O, Ilonen J, Knip M, Veijola R, Virtanen SM. Relationship of maternal weight status and weight gain rate during pregnancy to the development of advanced beta cell autoimmunity in the offspring: a prospective birth cohort study. Pediatr Diabetes 2011;12:478-484. doi: 10.1111/j.13995448.2010.00703.x.

114. Brown CT, Davis-Richardson AG, Giongo A, Crabb DB, Mukherjee N, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW. Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes. PLoS ONE 2011;6:e25792. doi: 10.1371/journal.pone.0025792.

115. Erkkola M, Kyttälä P, Takkinen H-M, Kronberg-Kippilä C, Nevalainen J, Simell O, Ilonen J, Veijola R, Knip M, Virtanen SM. Nutrient intake variability and number of days needed to assess intake in preschool children. Br J Nutr 2011;106:130-140. doi: 10.1017/S0007114510005167.

116. Forbes JM, Söderlund J, Yap FYT, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop P-H. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia 2011;54:1032-1042. doi: 10.1007/s00125-011-2058-z.

117. Forbes JM, Söderlund J, Yap FYT, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop P-H. Erratum to: Receptor for advanced glycation endproducts (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia 2011;54:1586-1587. doi: 10.1007/s00125-011-2145-1.

118. Giongo A, Gano KA, Crabb DB, Mukherjee N, Novelo LL, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 2011;5:82-91. doi: 10.1038/ismej.2010.92.

119. Lumia M, Luukkainen P, Tapanainen H, Kaila M, Erkkola M, Uusitalo L, Niinistö S, Kenward MG, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatr Allergy Immunol 2011;22:827-835. doi: 10.1111/j.1399-3038.2011.01202.x.

120. Nwaru BI, Erkkola M, Ahonen S, Kaila M, Lumia M, Prasad M, Haapala AM, Kronberg-Kippilä C, Veijola R, Ilonen J, Simell O, Knip M, Virtanen SM. Maternal diet during lactation and allergic sensitization in the offspring at age of 5. Pediatr Allergy Immunol 2011;22:334-341. doi: 10.1111/j.1399-3038.2010.01114.x.

121. Nwaru BI, Erkkola M, Ahonen S, Kaila M, Kronerg-Kippilä C, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring. Eur J Clin Nutr 2011;65:937-943. doi: 10.1038/ejcn.2011.67.

122. Nwaru BI, Lumia M, Kaila M, Luukkainen P, Tapanainen H, Erkkola M, Ahonen S, Pekkanen J, Klaukka T, Veijola R, Simell O, Knip M, Virtanen SM. Validation of the Finnish ISAAC questionnaire on asthma against anti-asthmatic medication reimbursement database in 5-yearold children. Clin Resp J 2011;5:211-218. doi: 10.1111/j.1752-699X.2010.00222.x.

123. Oikarinen S, Martiskainen M, Tauriainen S, Huhtala H, Ilonen J, Veijola R, Simell O, Knip M, Hyöty H. Enterovirus RNA in Blood is Linked to the Development of Type 1 Diabetes. Diabetes 2011;60:276-279. doi: 10.2337/db10-0186.

124. Prasad M, Takkinen H-M, Nevalainen J, Ovaskainen M-L, Alfthan G, Uusitalo L, Kenward MG, Veijola R, Simell O, Ilonen J, Knip M, SM. Are serum α- and β-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes? Diabetes Metab 2011;37:162-167. doi: 10.1016/j.diabet.2010.10.002.

125. Ryhänen SJ, Härkönen T, Siljander H, Näntö-Salonen K, Simell T, Hyöty H, Ilonen J, Veijola R, Simell O, Knip M. Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes. Diabetes Care 2011;34:1383-1388. doi: 10.2337/dc10-1449.

126. Seppälä E, Viskari H, Hoppu S, Honkanen H, Huhtala H, Simell O, Ilonen J, Knip M, Hyöty H. Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media. Vaccine 2011;29:8615-8618. doi: 10.1016/j.vaccine.2011.09.015.

127. Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M. Metabolic Regulation in Progression to Autoimmune Disease. PLoS Comput Biol 2011;7:e1002257. doi: 10.1371/journal.pcbi.1002257.

128. Virtanen SM, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg-Kippilä C, Ovaskainen M-L, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M. Maternal food consumption during pregnancy and risk of advance β-cell autoimmunity in the offspring. Pediatr Diabetes 2011;12:95-99. doi: 10.1111/j.13995448.2010.00668.x.

129. Virtanen SM, Takkinen H-M, Nevalainen J, Kronberg-Kippilä C, Salmenhaara M, Uusitalo L, Kenward MG, Erkkola M, Veijola R, Simell O, Ilonen J, Knip M. Early introduction of root vegetables in infancy associated with advanced β-cell autoimmunity in young children with human leukocyte antigen-conferred susceptibility to Type 1 diabetes. Diabetic Med 2011;28:965-971. doi: 10.1111/j.1464-5491.2011.03294.x

2012

130. Erkkola M, Nwaru BI, Kaila M, Kronberg-Kippilä C, Ilonen J, Simell O, Veijola R, Knip M, Virtanen SM. Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study. Pediatr Allergy Immunol 2012;23;186-194. doi: 10.1111/j.1399-3038.2012.01272.x.

131. Karjalainen AK, Hirvonen T, Kiviranta H, Sinkko H, Kronberg-Kippilä C, Virtanen SM, Hallikainen A, Leino O, Knip M, Veijola R, Simell O, Tuomisto JT. Long-term daily intake estimates of polychlorinated dibenzo-p-dioxins and furans, polychlorinated biphenyls and polybrominated diphenylethers from food in Finnish children: risk assessment implications. Food Addit Contam: Part A 2012;29:1475-1488. doi: 10.1080/19440049.2012.694373.

132. Kolehmainen P, Oikarinen S, Koskiniemi M, Simell O, Ilonen J, Knip M, Hyöty H, Tauriainen S. Human parechoviruses are frequently detected in stool of healthy Finnish children. J Clin Virol 2012;54:156-161. doi:10.1016/j.jcv.2012.02.006.

133. Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J. Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of ß-Cell Autoimmunity. Diabetes 2012;61:963-966. doi: 10.2337/db11-0386.

134. Lempainen J, Tauriainen S, Vaarala O, Mäkelä M, Honkanen H, Marttila J, Veijola R, Simell O, Hyöty H, Knip M, Ilonen J. Interaction of enterovirus infection and cow´s milk-based formula nutrition in type 1 diabetes-associated autoimmunity. Diabetes Metab Res Rev 2012;28:177185. doi: 10.1002/dmrr.1294.

135. Lumia M, Luukkainen P, Kaila M, Tapanainen H, Takkinen H-M, Prasad M, Niinistö S, Nwaru BI, Kenward MG, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Maternal dietary fat intake during lactation and the risk of asthma in the offspring. Acta Pædiatr 2012;101:e337-e343. doi: 10.1111/j.1651-2227.2012.02718.x.

136. Meriluoto M, Hedman L, Tanner L, Simell V, Mäkinen M, Simell S, Mykkänen J, Korpelainen J, Ruuskanen O, Ilonen J, Knip M, Simell O, Hedman K, Söderlund-Venermo M. Association of Human Bocavirus 1Infection with Respiratory Disease in Childhood Follow-up Study, Finland. Emerg Infect Dis 2012:18:264-271. doi: http://dx.doi.org/10.3201/eid1802.111293.

137. Nwaru BI, Erkkola M, Lumia M, Kronberg-Kippilä C, Ahonen S, Kaila M, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Maternal intake of fatty acids during pregnancy and allergies in the offspring. Br J Nutr 2012;108:720-732. doi: 10.1017/S0007114511005940.

138. Öling V, Reijonen H, Simell O, Knip M, Ilonen J. Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes. Cell Immunol 2012;273;133-139. doi: 10.1016/j.cellimm.2011.12.008.

139. Parikka V, Näntö-Salonen K, Saarinen M, Simell T, Ilonen J, Hyöty H, Veijola R, Knip M, Simell O. Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 2012;55:1926-1936. doi: 10.1007/s00125-012-2523-3.

140. Virtanen SM, Nevalainen J, Kronberg-Kippilä C, Ahonen S, Tapanainen H, Uusitalo L, Takkinen H-M, Niinistö S, Ovaskainen M-L, Kenward MG, Veijola R, Ilonen J, Simell O, Knip M. Food consumption and advanced ß cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design. Am J Clin Nutr 2012;95:471478. doi: 10.3945/ajcn.111.018879.

141. Viskari H, Knip M, Tauriainen S, Huhtala H, Veijola R, Ilonen J, Simell O, Surcel H-M, Hyöty H. Maternal Enterovirus Infection as a Risk Factor for Type 1 Diabetes in the Exposed Offspring. Diabetes Care 2012;35:1328-1332. doi: 10.2337/dc11-2389.

2013

142. Erkkola M, Salmenhaara M, Nwaru BI, Uusitalo L, Kronberg-Kippilä C, Ahonen S, Veijola R, Knip M, Virtanen SM. Sociodemographic determinants of early weaning: a Finnish birth cohort study in infants with human leucocyte antigen-conferred susceptibility to type 1 diabetes. Public Health Nutr 2013;16:296-304. doi: 10.1017/S1368980012002595.

143. Honkanen H, Oikarinen S, Peltonen P, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H. Human rhinoviruses including group C are common in stool samples of young Finnish children. J Clin Virol 2013;56:250-254. doi: 10.1016/j.jcv.2012.11.020.

144. Honkanen H, Oikarinen S, Pakkanen O, Ruokoranta T, Pulkki MM, Laitinen OH, Tauriainen S, Korpela S, Lappalainen M, Vuorinen T, Haapala A-M, Veijola R, Simell O, Ilonen J, Knip M, Hyöty H. Human enterovirus 71 strains in the background population and in hospital patients in Finland. J Clin Virol 2013;56:348-353. doi: 10.1016/j.jcv.2012.11.018.

145. Ilonen J, Hammais A, Laine AP, Lempainen J, Vaarala O, Veijola R, Simell O, Knip M. Patterns of ß-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life. Diabetes 2013;62:3636-3640. doi: 10.2337/db13-0300.

146. Karjalainen AK, Hallikainen A, Hirvonen T, Kiviranta H, Knip M, Kronberg-Kippilä C, Leino O, Simell O, Sinkko H, Tuomisto JT, Veijola R, Venäläinen E-R, Virtanen SM. Estimated intake levels for Finnish children of methylmercury from fish. Food Chem Toxicol 2013;54:70-77. doi: 10.1016/j.fct.2012.02.074.

147. Kolehmainen P, Koskiniemi M, Oikarinen S, Veijola R, Simell O, Ilonen J, Knip M, Hyöty H, Tauriainen S. Human Parechovirus and the Risk of Type 1 Diabetes. J Med Virol 2013;85:1619-1623. doi: 10.1002/jmv.23659.

148. Korhonen L, Kondrashova A, Tauriainen S, Haapala AM, Huhtala H, Ilonen J, Simell O, Knip M, Lönnrot M, Hyöty H. Enterovirus infections in early childhood and the risk of atopic disease – a nested case-control study. Clin Exp Allergy 2013;43:625-632. doi: 10.1111/cea.12068.

149. Lähdeaho M-L, Ukkola O, Jokela M, Huhtala H, Knip M, Kesäniemi YA, Kuusela A-L. Peptide hormones in infants with feeding disorders. Scand J Clin Lab Invest 2013;73:387-391. doi: 10.3109/00365513.2013.786122.

150. Nwaru BI, Takkinen H-M, Niemelä O, Kaila M, Erkkola M, Ahonen S, Haapala AM, Kenward MG, Pekkanen J, Lahesmaa R, Kere J, Simell O, Veijola R, Ilonen J, Hyöty H, Knip M, Virtanen SM. Timing of infant feeding in relation to childhood asthma and allergic diseases. J Allergy Clin Immunol 2013;131:78-86. doi: 10.1016/j.jaci.2012.10.028.

151. Nwaru BI, Takkinen H-M, Niemelä O, Kaila M, Erkkola M, Ahonen S, Tuomi H, Haapala A-M, Kenward MG, Pekkanen J, Lahesmaa R, Kere J, Simell O, Veijola R, Ilonen J, Hyöty H, Knip M, Virtanen SM. Introduction of complementary foods in infancy and atopic sensitization at the age of 5 years: timing and food diversity in a Finnish birth cohort. Allergy 2013;68:507516. doi: 10.1111/all.12118.

152. Orešič M, Gopalacharyulu P, Mykkänen J, Lietzen N, Mäkinen M, Nygren H, Simell S, Simell V, Hyöty H, Veijola R, Ilonen J, Sysi-Aho M, Knip M, Hyötyläinen T, Simell O. Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes. Diabetes 2013;62:32683274. doi: 10.2337/db13-0159.

153. Siljander HT, Hermann R, Hekkala A, Lähde J, Tanner L, Keskinen P, Ilonen J, Simell O, Veijola R, Knip M. Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced -cell autoimmunity. Eur J Endocrinol 2013;169:479-485. doi: 10.1530/EJE-130206.

154. Simonen-Tikka, M-L, Klemola P, Suomenrinne S, Kaijalainen S, Söderström D, Savolainen-Kopra C, Näntö-Salonen K, Ilonen J, Simell T, Simell O, Roivainen M. Virus Infections Among Young Children-the First Year of the Indis Study. J Med Virol, 2013;85:1678-1684. doi: 10.1002/jmv.23625.

155. Uusitalo L, Nevalainen J, Salminen I, Ovaskainen M-L, Kronberg-Kippilä C, Ahonen S, Niinistö S, Alfthan G, Simell O, Ilonen J, Veijola R, Knip M, Virtanen SM. Fatty acids in serum and diet – a canonical correlation analysis among toddlers. Maternal & Child Nutrition 2013;9:381395. doi: 10.1111/j.1740-8709.2011.00374.x.

156. Westerhuis B, Kolehmainen P, Benschop K, Nurminen N, Koen G, Koskiniemi M, Simell O, Knip M, Hyöty H, Wolthers K, Tauriainen S. Human parechovirus seroprevalence in Finland and the Netherlands. J Clin Virol 2013;58:211-215. doi: 10.1016/j.jcv.2013.06.036.

157. Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS. Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children. JAMA 2013;309:2473-2479. doi: 10.1001/jama.2013.6285.

2014

158. Chen T, Tanner L, Simell V, Hedman L, Mäkinen M, Sadeghi M, Veijola R, Hyöty H, Ilonen J, Knip M, Toppari J, Simell O, Söderlund-Venermo M, Hedman K. Diagnostic Methods for and
Clinical Picture of Polyomavirus Primary Infections in Children, Finland. Emerg Infect Dis 2014;20:689-692. doi: 10.3201/eid2004.131015.

159. Davis-Richardson AG, Ardissone AN, Dias R, Simell V, Leonard MT, Kemppainen KM, Drew JC, Schatz D, Atkinson MA, Kolaczkowski B, Ilonen J, Knip M, Toppari J, Nurminen N, Hyöty H, Veijola R, Simell T, Mykkänen J, Simell O, Triplett EW. Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes. Front Microbiol 2014, 5:678. doi: 10.3389/fmicb.2014.00678.

160. Kallionpää H, Elo LL, Laajala, E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Innate Immune Activity is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility. Diabetes 2014;63:2402-2414. doi: 10.2337/db13-1775.

161. Kyttälä P, Erkkola M, Lehtinen-Jacks S, Ovaskainen M-L, Uusitalo L, Veijola R, Simell O, Knip M, Virtanen SM. Finnish Children Healthy Eating Index (FCHEI) and its associations with family and child characteristics in pre-school children. Public Health Nutr 2014;17:2519-2527. doi: 10.1017/S1368980013002772.

162. Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H. Coxsackievirus B1 is Associated With Induction of Cell Autoimmunity That Portends Type 1 Diabetes. Diabetes 2014;63;446-455. doi: 10.2337/db13-0619.

163. Leonard MT, Davis-Richardson AG, Ardissone AN, Kemppainen KM, Drew JC, Ilonen J, Knip M, Simell O, Toppari J, Veijola R, Hyöty H, Triplett EW. The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei. Front Microbiol 2014;5:361. doi: 10.3389/fmicb.2014.00361.

164. Lumia M, Luukkainen P, Takkinen H-M, Kaila M, Nwaru BI, Nevalainen J, Salminen I, Uusitalo L, Niinistö S, Tuokkola J, Niemelä O, Haapala A-M, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. (Letter) Cow´s milk allergy and the association between fatty acids and childhood asthma risk. J Allergy Clin Immunol 2014;134:488-490. doi: 10.1016/j.jaci.2014.04.012.

165. Mäkinen M, Simell V, Mykkänen J, Ilonen J, Veijola R, Hyöty H, Knip M, Simell O, Toppari J, Hermann R. An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children. J Clin Endocrinol Metab 2014;99:E2353E2356. doi: 10.1210/jc.2014-1455.

166. Mikk M-L, Kiviniemi M, Laine A-P, Härkönen T, Veijola R, Simell O, Knip M, Ilonen J, the Finnish Paediatric Diabetes Register. The HLA-B39 allele increases type 1 diabetes risk conferred by HLA-DRB104:04-DQB103:02 and HLA-DRB108-DQB1*04 class II haplotypes. Hum Immunol 2014;75:65-70. doi: 10.1016/j.humimm.2013.09.008.

167. Niinistö S, Takkinen H-M, Uusitalo L, Rautanen J, Nevalainen J, Kenward MG, Lumia M, Simell O, Veijola R, Ilonen J, Knip M, Virtanen SM. Maternal dietary fatty acid intake during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring. Br J Nutr 2014;111:895-903. doi: 10.1017/S0007114513003073.

168. Nwaru BI, Takkinen H-M, Kaila M, Erkkola M, Ahonen S, Pekkanen JP, Simell O, Veijola R, Ilonen J, Hyöty H, Knip M, Virtanen SM. Food diversity in infancy and the risk of childhood asthma and allergies. J Allergy Clin Immunol 2014;133:1084-1091. doi: 10.1016/j.jaci.2013.12.1069.

169. Oikarinen S, Tauriainen S, Hober D, Lucas B, Vazeou A, Sioofy-Khojine A, Bozas, E, Muir P, Honkanen H, Ilonen J, Knip M, Keskinen P, Saha M-T, Huhtala H, Stanway G, Bartsocas CS, Ludvigsson J, Taylor K, Hyöty H, VirDiab Study Group. Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes. Diabetes 2014;63:655-662. doi: 10.2337/db13-0620.

170. Talja I, Kubo A-L, Veijola R, Knip M, Simell O, Ilonen J, Vähä-Mäkilä M, Sepp E, Mikelsaar M, Utt M, Uibo R. Antibodies to Lactobacilli and Bifidobacteria in Young Children with Different Propensity to Develop Islet Autoimmunity. J Immunol Res 2014;2014:325938. doi: 10.1155/2014/325938.

171. Virtanen SM, Takkinen H-M, Nwaru BI, Kaila M, Ahonen S, Nevalainen J, Niinistö S, Siljander H, Simell O, Ilonen J, Hyöty H, Veijola R, Knip M. Microbial Exposure in Infancy and Subsequent Appearance of Type 1 Diabetes Mellitus-Associated Autoantibodies: A Cohort Study. JAMA Pediatr. 2014;168:755-763. doi: 10.1001/jamapediatrics.2014.296.

2015

172. Acevedo N, Reinius LE, Vitezic M, Fortino V, Söderhäll C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyöty H, Greco D, Kere J. Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human leukocytes. Clin Epigenet 2015;7:34. doi: 10.1186/s13148015-0064-6.

173. Blazevic V, Malm M, Salminen M, Oikarinen S, Hyöty H, Veijola R, Vesikari T. Multiple consecutive norovirus infections in the first 2 years of life. Eur J Pediatr 2015;174:1679-1683. doi: 10.1007/s00431-015-2591-8.

174. Hamari S, Kirveskoski T, Glumoff V, Kulmala P, Simell O, Knip M, Ilonen J, Veijola R. CD4+ Tcell proliferation responses to wheat polypeptide stimulation in children at different stages of type 1 diabetes autoimmunity. Pediatr Diabetes 2015;16:177-188. doi: 10.1111/pedi.12256.

175. Helminen O, Aspholm S, Pokka T, Hautakangas M-R, Haatanen N, Lempainen J, Ilonen J, Simell O, Knip M, Veijola R. HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk. Diabetes 2015;64:1719-1727. doi: 10.2337/db14-0497.

176. Helminen O, Aspholm S, Pokka T, Ilonen J, Simell O, Veijola R, Knip M. OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis. Diabetologia 2015;58:1787-1796. doi: 10.1007/s00125-015-3621-9.

177. Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M. B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study. PLoS ONE 2015;10(9):e139096. doi: 10.1371/journal.pone.0139096.

178. Kondrashova A, Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hyöty H. Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children generally predisposed to type 1 diabetes. Diabetologia 2015;58:2592-2595. doi: 10.1007/s00125-015-3723-4.

179. Koskinen MK, Helminen O, Matomäki J, Aspholm S, Mykkänen J, Mäkinen M, Simell V, VähäMäkilä M, Simell T, Ilonen J, Knip M, Veijola R, Toppari J, Simell OG. Reduced β-cell function in early preclinical type 1 diabetes. Eur J Endocrinol 2015;174:251–259. doi: http://dx.doi.org/10.1530/EJE-15-0674.

180. Lammi A, Arikoski P, Simell S, Kinnunen T, Simell V, Paavanen-Huhtala S, Hinkkanen A, Veijola R, Knip M, Toppari J, Vaarala O, Simell O, Ilonen J. Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children. J Pediatr Gastroenterol Nutr 2015;60:626-631. doi: 10.1097/MPG.0000000000000666.

181. Lempainen J, Laine A-P, Hammais A, Toppari J, Simell O, Veijola R, Knip M, Ilonen J. Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease. J Autoimmun 2015;61:45-53. doi: 10.1016/j.jaut.2015.05.005.

182. Lumia M, Takkinen H-M, Luukkainen P, Kaila M, Lehtinen-Jacks S, Nwaru BI, Tuokkola J, Niemelä O, Haapala A-M, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Food consumption and risk of childhood asthma. Pediatr Allerg Immunol 2015; 26:789-96. doi: 10.1111/pai.12352.

183. Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort with HLA-Conferred Susceptibility. Diabetes 2015;64:2265-2278. doi: 10.2337/db14-0983.

184. Niinistö S, Takkinen H-M, Uusitalo L, Rautanen J, Vainio N, Ahonen S, Nevalainen J, Kenward MG, Lumia M, Simell O, Veijola R, Ilonen J, Knip M, Virtanen SM. Maternal intake of fatty acids and their food sources during lactation and the risk of preclinical and clinical type 1 diabetes in the offspring. Acta Diabetol 2015;52:763-772. doi: 10.1007/s00592-014-0673-0.

185. Salonen KM, Ryhänen SJ, Forbes JM, Borg DJ, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M. Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibcoy Positivity in Children With Prediabetes. Diabetes Care 2015;38:665-670. doi: 10.2337/dc14-1186.

186. Kramná L, Kolářova K, Oikarinen S, Pursiheimo J-P, Ilonen J, Simell O, Knip M, Veijola R, Hyöty H, Cinek O. Gut Virome Sequencing in Children With Early Islet Autoimmunity. Diabetes Care 2015;38:930-933. doi: 10.2337/dc14-2490.

187. van der Valk RJP, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo Y-Y, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Smith GD, Bergström A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M, Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CMT, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen A-L, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikäinen L-P, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw S-M, Holloway JW, Melén E, Grant SFA, Feenstra B, Lowe WL, Widén E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin M-R, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, Mccarthy MI, Frayling TM, Sunyer J, Timpson NJ, Rivadeneira F, Bønnelykke K, Jaddoe VWV for the Early Growth Genetics (EGG) Consortium. A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet 2015;24:1155-1168. doi: 10.1093/hmg/ddu510.

2016

188. Blazevic V, Malm M, Honkanen H, Knip M, Hyöty H, Vesikari T. Development and Maturation of Norovirus antibodies in Childhood. Microbes Infect 2016 18(4):263-9. doi: 10.1016/j.micinf.2015.12.004.

189. Borges IC, Andrade DC, Cardoso MR, Toppari J, Vähä-Mäkilä M, Ilonen J, Knip M, Hyöty H, Veijola R, Simell O, Jartti T, Käyhty H, Ruuskanen O, Nascimento-Carvalho CM. Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life. Clin Vaccine Immunol. 2016;23(11):878-883. doi: 10.1128/CVI.00341-16.

190. Hamari S, Kirveskoski T, Glumoff V, Kulmala P, Simell O, Knip M, Veijola R. Analyses of regulatory CD4(+) CD25(+) FOXP3(+) T cells and observations from peripheral T cell subpopulation markers during the development of type 1 diabetes in children. Scand J Immunol. 2016;83(4):279-87. doi: 10.1111/sji.12418.

191. Helminen O, Pokka T, Tossavainen P, Ilonen J, Knip M, Veijola R. Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus. Diabetes Res Clin Pract. 2016;120:89-96. doi: 10.1016/j.diabres.2016.07.027.

192. Mäkinen M, Mykkänen J, Koskinen M, Simell V, Veijola R, Hyöty H, Ilonen J, Knip M, Simell O, Toppari J. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab 2016;101:723-729. doi: 10.1210/jc.2015-3504.

193. Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H. Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study. J Clin Virol. 2016;85:1-6. doi: 10.1016/j.jcv.2016.10.010.

194. Tuokkola J, Luukkainen P, Kaila M, Takkinen HM, Niinistö S, Veijola R, Virta LJ, Knip M, Simell O, Ilonen J, Virtanen SM. Maternal dietary folate, folic acid and vitamin D intakes during pregnancy and lactation and the risk of cows’ milk allergy in the offspring. Br J Nutr 2016 Aug;116:710-718. doi: 10.1017/S0007114516002464.

195. Tuokkola J, Luukkainen P, Tapanainen H, Kaila M, Vaarala O, Kenward MG, Virta LJ, Veijola R, Simell O, Ilonen J, Knip M, Virtanen SM. Maternal diet during pregnancy and lactation and cow’s milk allergy in offspring. Eur J Clin Nutr. 2016 70:554-559. doi: 10.1038/ejcn.2015.223.

2017

196. Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H. Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls. Pediatr Diabetes 2017;18:588-598. doi: 10.1111/pedi.12468.

197. Hakola L, Takkinen HM, Niinistö S, Ahonen S, Erlund I, Rautanen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM, Lehtinen-Jacks S. Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study. Pediatr Obes. 2017 12:26-37. doi: 10.1111/ijpo.12170.

198. Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H. Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity. Diabetologia 2017 60:424-431. doi: 10.1007/s00125-016-4177-z.

199. Hämäläinen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM. Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study. Clin Exp Allergy 017 47:401-409. doi: 10.1111/cea.12904.

200. Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M. Correction: BCell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study. PLoS One 2017 8;12(2):e0172078. doi: 10.1371/journal.pone.0172078. eCollection 2017.

201. Knip M, Selvenius J, Siljander H, Veijola R. Reclassification of asymptomatic beta cell autoimmunity: a critical perspective. Diabetologia 2017 60:39-42. doi: 10.1007/s00125-0164147-5.

202. Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register. The association of the HLA-A24:02, B39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns. HLA 2017 89:215-224. doi: 10.1111/tan.12967.

203. Niinistö S, Takkinen HM, Erlund I, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Vaarala O, Virtanen SM. Fatty acid status in infancy is associated with the risk of type 1 diabetesassociated autoimmunity. Diabetologia. 2017 60:1223-1233. doi: 10.1007/s00125-017-42809.

204. Nwaru BI, Hadkhale K, Hämäläinen N, Takkinen HM, Ahonen S, Ilonen J, Toppari J, Niemelä O, Haapala AM, Veijola R, Knip M, Virtanen SM. Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study. Pediatr Allergy Immunol 2017;28:641648. doi: 10.1111/pai.12773.

205. Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vähäsalo P, Ilonen J, Siljander H, Knip M. Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. Diabetologia 2017;60:1284-1293. doi: 10.1007/s00125-017-4258-7.

206. Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M. A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes. Diabetes Metab Res Rev 2017;33(4) doi: 10.1002/dmrr.2872.

207. Tuokkola J, Luukkainen P, Nevalainen J, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Virtanen SM, Kaila M. Eliminating cows’ milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies. Acta Paediatr 2017;106:1142-1149. doi: 10.1111/apa.13846.

208. Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes 2017 66:437-447. doi: 10.2337/db16-0714.

2018

209. Hakola L, Takkinen HM, Niinistö S, Ahonen S, Nevalainen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM. Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study. Am J Epidemiol 2018;187:34-44. doi: 10.1093/aje/kwx191.

210. Hekkala A, Ilonen J, Toppari J, Knip M, Veijola R. Ketoacidosis at diagnosis of type 1 diabetes: effect of prospective studies with newborn genetic screening and follow-up of risk children. Pediatric Diabetes 2018;19:314-319. doi: 10.1111/pedi.12541. Epub 2017 May 23.

211. Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes. J Immunol 2018;201(4):1144-1153. doi: 10.4049/jimmunol.1701199.

212. Ilonen J, Lempainen J, Hammais A, Laine AP, Härkönen T, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register. Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity. Pediatr Diabetes 2018;19:284-292. doi: 10.1111/pedi.12545. Epub 2017 Jun 9.

213. Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H. Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children. Pediatr Diabetes 2018;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 17.

214. Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H.
Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring. Clin Exp Allergy 2018;48(12):1698-1704. doi: 10.1111/cea.13280.

215. Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R. Class II HLA Genotype Association with First Phase Insulin Response Is Explained by Islet Autoantibodies. J Clin Endocrinol Metab 2018;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

216. Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M. Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP). Sci Rep 2018;8(1):10635. doi: 10.1038/s41598-018-28907-8.

217. Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M. A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Sci Data 2018;5:180250. doi: 10.1038/sdata.2018.250.

218. Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL. Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes. Diabetologia 2018;61:381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

219. Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM. Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption. Nutrients 2018;10(10). pii: E1533. doi: 10.3390/nu10101533.

220. Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H. Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes. Diabetologia 2018;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y.

221. Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H. Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study. Diabetologia 2018;61:203-209. doi:10.1007/s00125-017-4410-4. Epub 2017 Sept 2.

2019

222. Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A, Ilonen J. Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood. J Clin Endocrinol Metab. 2019;104(10):4521-4530. doi: 10.1210/jc.2019-00421.

223. Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T. Circulating CXCR5(-)PD-1(hi) peripheral T helper cells are associated with progression to type 1 diabetes. Diabetologia 2019;62(9):1681-1688. doi: 10.1007/s00125-0194936-8. Epub 2019 Jul 3. PubMed PMID: 31270583.

224. Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J. Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes. Pediatr Diabetes 2019;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

225. Hakola L, Miettinen ME, Syrjälä E, Åkerlund M, Takkinen HM, Korhonen TE, Ahonen S, Ilonen J, Toppari J, Veijola R, Nevalainen J, Knip M, Virtanen SM. Association of Cereal, Gluten,
and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes. JAMA Pediatr. 2019 Aug 12. doi: 10.1001/jamapediatrics.2019.2564. [Epub ahead of print]

226. Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H. No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort. Pediatr Infect Dis J 2019;38(3):314-316. doi: 10.1097/INF.0000000000002201.

227. Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules 2019;9(1). pii: E33. doi: 10.3390/biom9010033.

228. Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M. Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia 2019;62(12):2287-2297. doi: 10.1007/s00125-019-04980-0. Epub 2019 Aug 23.

229. Malm M, Hyöty H, Knip M, Vesikari T, Blazevic V. Development of T cell immunity to norovirus and rotavirus in children under five years of age. Sci Rep 2019;9(1):3199. doi: 10.1038/s41598019-39840-9.

230. Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J. Serum 25Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes. J Clin Endocrinol Metab 2019 Jun 1;104(6):2277-2285. doi: 10.1210/jc.2018-02094.

231. Ojwang V, Nwaru BI, Takkinen HM, Kaila M, Niemelä O, Haapala AM, Ilonen J, Toppari J, Hyöty H, Veijola R, Knip M, Virtanen SM. Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy. Pediatr Allergy Immunol 2019 Dec 12. doi: 10.1111/pai.13186. [Epub ahead of print]

232. Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Ilonen J, Siljander H, Knip M. Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLAConferred Disease Risk. J Clin Endocrinol Metab 2019 Nov 1;104(11):5585-5594. doi: 10.1210/jc.2019-01069.

233. Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M. Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clin Transl Gastroenterol 2019;10(5):1-10. doi: 10.14309/ctg.0000000000000044. PubMed PMID: 31082858.

234. Syrjälä E, Nevalainen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM. A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity. Sci Rep 2019;9(1):7760. doi: 10.1038/s41598-019-44196-1. PubMed PMID: 31123290; PubMed Central PMCID: PMC6533366.

235. Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children. Front Immunol 2019;10:19. doi:10.3389/fimmu.2019.00019.

2020

236. Ihantola EL, Ilmonen H, Kailaanmäki A, Rytkönen-Nissinen M, Azam A, Maillère B, Lindestam Arlehamn CS, Sette A, Motwani K, Seay HR, Brusko TM, Knip M, Veijola R, Toppari J, Ilonen
J, Kinnunen T. Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 DiabetesAssociated HLA Class II Molecules. J Immunol 2020 Mar 30:ji1901079. doi: 10.4049/jimmunol.1901079. Online ahead of print.

237. Koivusaari K, Syrjälä E, Niinistö S, Takkinen HM, Ahonen S, Åkerlund M, Korhonen TE, Toppari J, Ilonen J, Peltonen J, Nevalainen J, Knip M, Alatossava T, Veijola R, Virtanen SM. Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity. Br J Nutr 2020 Feb 27:1-17. doi: 10.1017/S0007114520000744. Online ahead of print.

238. Koskinen MK, Mikk ML, Laine AP, Lempainen J, Löyttyniemi E, Vähäsalo P, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Veijola R, Ilonen J, Toppari J. Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies. Diabetes 2020 Jan;69(1):12-19. doi: 10.2337/db19-0329. Epub 2019 Oct 7

239. Sane F, Bertin A, Sioofy-Khojine AB, Oikarinen S, Alidjinou EK, Veijola R, Toppari J, Ilonen J, Knip M, Engelmann I, Hyöty H, Hober D. Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes. Diabetes Metab Res Rev 2020 Mar 2:e3305. doi: 10.1002/dmrr.3305. Online ahead of print.

240. Sen P, Dickens AM, López-Bascón MA, Lindeman T, Kemppainen E, Lamichhane S, Rönkkö T, Ilonen J, Toppari J, Veijola R, Hyöty H, Hyötyläinen T, Knip M, Orešič M. Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia 2020 Feb 11. doi: 10.1007/s00125-020-05107-6. Online ahead of print.

241. Valta M, Gazali AM, Viisanen T, Ihantola EL, Ekman I, Toppari J, Knip M, Veijola R, Ilonen J, Lempainen J, Kinnunen T. Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells. Eur J Immunol 2020;50(4):581-588. doi: 10.1002/eji.201948378. Epub 2019 Dec 19.

242. Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M. Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clin Exp Immunol 2020;199(3):263-277. doi: 10.1111/cei.13391. Epub 2019 Nov 10.

Review articles

1. Hyöty H. Enterovirus infections and type 1 diabetes. Ann Med 2002;34:138-147. doi: 10.1080/ann.34.3.138.147.

2. Ilonen J, Sjöroos M, Knip M, Veijola R, Simell O, Åkerblom HK, Paschou P, Bozas E, Havarani B, Malamitsi-Puchner A, Thymelli J, Bartsocas CS. Estimation of Genetic Risk for Type 1 Diabetes. Am J Med Genet 2002;115:30-36. doi: 10.1002/ajmg.10341.

3. Knip M, Kukko M, Kulmala P, Veijola R, Simell O, Åkerblom HK, Ilonen J. Humoral Beta-Cell Autoimmunity in Relation to HLA-Defined Disease Susceptibility in Preclinical and Clinical Type 1 Diabetes. Am J Med Genet 2002;115:48-54. doi: 10.1002/ajmg.10343.

4. Tauriainen S, Salminen K, Hyöty H. Can Enteroviruses Cause Type 1 Diabetes? Ann N Y Acad Sci 2003;1005:13-22. doi: 10.1196/annals.1288.003.

5. Hyöty H. Environmental causes: viral causes. Endocrin Metab Clin North Am 2004;33:27-44. doi: 10.1016/j.ecl.2003.12.004.

6. Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Åkerblom HK. Environmental Triggers and Determinants of Type 1 Diabetes. Diabetes 2005;54,Suppl.2:S125-S136. doi: 10.2337/diabetes.54.suppl_2.S125.

7. Hyöty H. Enteroviruses and Type-1 Diabetes: Overview of Epidemiological Studies. J Med Virol 2009;81:197-198. doi: 10.1002/jmv.21354.

8. Tauriainen S, Oikarinen S, Oikarinen M, Hyöty H. Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol 2011;33:45-55. doi: 10.1007/s00281-010-0207-y.

9. Knip M, Simell O. Environmental triggers of type 1 diabetes. Cold Spring Harb Perspect Med 2012;2:a007690. doi: 10.1101/cshperspect.a007690.

10. Lempainen J, Ilonen J. Influence of Type 1 Diabetes Genes on Disease Progression: Similarities and Differences Between Countries. Curr Diab Rep 2012;12:447-455. doi: 10.1007/s11892-0120310-7.

11. Nurminen N, Oikarinen S, Hyöty H. Virus Infections as Potential Targets of Preventive Treatments for Type 1 Diabetes. Rev Diabet Stud 2012;9:260-271. doi: 10.1900/RDS.2012.9.260.

12. Ilonen J, Knip M, Vaarala O. Heterogeneity in diabetes-associated autoantibodies and susceptibility to Type 1 diabetes: lessons for disease prevention. Expert Rev Endocrinol Metab 2015;10:2534. doi: 10.1586/17446651.2015.955474.

13. Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol. 2016;12:154-167. doi: 10.1038/nrendo.2015.218.

14. Hyöty H. Viruses in type 1 diabetes. Pediatr Diabetes. 2016;17 (Suppl 22):56-64. doi: 10.1111/pedi.12370. doi: 10.1128/CVI.00341-16.

15. Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register. Genetic susceptibility to type 1 diabetes in childhood – estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity. Pediatr Diabetes. 2016;17 (Suppl 22):8-16. doi: 10.1111/pedi.12327.

16. Knip M, Siljander H, Ilonen J, Simell O, Veijola R. Role of humoral beta-cell autoimmunity in type 1 diabetes. Pediatr Diabetes. 2016; 17 (Suppl 22):17-24. doi: 10.1111/pedi.12386.

17. Veijola R, Koskinen M, Helminen O, Hekkala A. Dysregulation of glucose metabolism in preclinical type 1 diabetes. Pediatr Diabetes. 2016;17 (Suppl 22):25-30. doi: 10.1111/pedi.12392.

18. Knip M. Diabetes: Loss of β-cell mass – an acute event before T1DM presentation? Nat Rev Endocrinol. 2017 13:253-254. doi: 10.1038/nrendo.2017.33.

19. Ilonen J, Lempainen J, Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol 2019 Nov;15(11):635-650. doi: 10.1038/s41574-019-0254-y. Epub 2019 Sep 18. Review.

Conference proceedings

1. Ilonen J, Reijonen H, Sjöroos M, Nejentsev S, Knip M, Simell O. Genetic screening for type 1 diabetes based on HLA-DQ typing in the general population. The Finnish diabetes prediction and prevention study. (B) In: JA Hansen, ed, Immunobiology of the human MHC. Proceedings of the 13th International Histocompatibility Workshop and Conference and the XIII International Congress of Histocompatibility and Immunogenetics. Vol II, IHWG Press, Seattle, WA, USA, 2006;368-371

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